Postdoctoral Fellow - Biochemical Cellular Pharmacology- Chen Lab/Stanford-Du Bois Lab

The Genentech/Stanford ChEM-H Institute is seeking a highly motivated postdoctoral fellow to study ion channels involved in human diseases. The successful candidate will be co-mentored by Dr. Jun Chen (Genentech) and Professor Justin Du Bois (Stanford University), and spend ~50% time at their respective labs. The candidate will be funded for up to 4 years by Genentech, and have the opportunity to study ion channel biophysics and physiology essential for understanding human physiology and diseases, and for guiding therapeutic development. The postdoc will employ a combination of techniques including electrophysiology, chemical biology, molecular biology, and structural biology, and will have the opportunity of interacting with scientists in the broad Genentech and Stanford research communities. The postdoc is expected to make fundamental scientific discovery, publish in top-tier journals and present in external conferences.

Applicants should have a recent doctoral degree in biophysics, pharmacology, neuroscience, chemical biology or related disciplines. A scientific track record evidenced by at least one first author paper published or accepted in a well-recognized journal. Technical expertise in at least two areas, including electrophysiology, molecular biology, pharmacology, proteomics, and synthetic chemistry. Rigorous scientific aptitude, enthusiasm for learning, and desire to solve complex problems independently and in a collaborative environment. Strong oral and written communication skills.

A Non-covalent Ligand Reveals Biased Agonism at the TRPA1 Ion Channel

Neuron 2021, 109, 1-12

Conservation and divergence in NaChBac and NaV1.7 pharmacology reveals novel drug interaction mechanisms  

Sci Report 2020, 10(1):10730

TRPA1 modulation by piperidine carboxamides suggests an evolutionarily conserved binding site and gating mechanism

PNAS 2019, 116(51): 26008-26019

Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors PNAS 2018, 15(4): E792-E801

Precise spatiotemporal control of voltage-gated sodium channels by photocaged saxitoxin

Nat. Comm. 2021, 12, 4171

Development and validation of a potent and specific inhibitor for the CLC-2 chloride channel

Proc. Natl. Acad. Sci. 2020, 202009977

Discovery of a Selective, State-Independent Inhibitor of NaV1.7 by Modification of Guanidinium Toxins

Scientific Reports 2020, 10, article number 14791

Structure of the saxiphilin:saxitoxin (STX) complex reveals a convergent molecular recognition strategy for paralytic toxins

Science Advances 2019, 5, eaax2650

Genentech is the founder and leader of biotech industry, and Genentech Postdoctoral Program emphasizes basic and fundamental discovery research, with the mission of conducting first-rate science and publish in top-tier journals. Genentech’s postdocs are funded for up to 4 years, and they form a vibrant community with their own external speaker seminar program, off-site, and internal research meetings. The program is known for the quality and impact of its publications, as well as the outstanding careers of many former fellows in academia and industry.

For more information about the postdoctoral program at Genentech, please visit:

https://www.gene.com/careers/university-and-early-career/postdocs

Stanford University is a top research institution in the world, and its ChEM-H program is building bridges across the postdoctoral scholar community in chemistry, engineering, and medicine to encourage the execution of innovative research aimed at addressing challenges in human health from a multi-disciplinary perspective. For more information about Stanford ChEM-H program, please visit:

https://chemh.stanford.edu/programs/postdoc-programs