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Postdoctoral Research Fellow - Structural Biology, Dimitrova Lab

The position
We have an opening for a highly motivated postdoctoral fellow with a strong background in biochemistry and structural biology to join the Dimitrova lab in the Structural Biology Department at Genentech. The postdoc will work in a highly collaborative group, studying the function and regulation of macromolecular assemblies important in fundamental cellular processes and human disease. The successful candidate will have access to cutting edge structural biology techniques, X-ray crystallography, a well-equipped state-of-the-art cryoEM facility, and the opportunity to work in a highly stimulating and scientifically rich environment. The projects will involve working closely with groups across different therapeutic areas, both within Genentech and academia. 
    
Who you are:

  • Candidates must have a PhD in structural biology, biochemistry, or a related field, with one or more first-author publications in high quality journals.
  • Successful experience with expression and purification of multi-protein complexes from multiple recombinant sources is required.
  • Prior experience with biochemical/biophysical characterization and structure determination of proteins by X-ray crystallography and/or single-particle cryoEM is required.
  • Experience in protein engineering, biophysical characterization methods for protein-protein and protein-nucleic acid interactions (such as surface-plasmon resonance, Isothermal Titration Calorimetry,or bio-layer interferometry), or in vitro assay development are beneficial.
  • Self-motivated and detail-oriented researcher, driven to solve complex scientific problems independently and in a collaborative environment.
  • Strong oral and written communication skills are required.
For more information about the Dimitrova's Lab:
More Information about the Genentech Postdoctoral Program:

http://www.gene.com/careers/academic-programs/postdocs
Relevant publications:
Hamilton GE, Helgeson LA, Noland CL, Asbury CL, Dimitrova YN, Davis TN (2020) Reconstitution
reveals two paths of force transmission through the kinetochore. eLife.
Migl, D, Kschonsak M, Arthur CP, Khin Y, Harrison SC, Ciferri C, Dimitrova YN (2020) Cryoelectron microscopy structure of a yeast centromeric nucleosome at 2.7 Å resolution. Structure. 28, 363-370.
     
Dimitrova YN, Jenni S, Valverde R,  Khin Y, Harrison SC (2016)  Structure of the  MIND  complex defines a regulatory focus for yeast kinetochore assembly. Cell. 167(4): 1014-1027