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Summer Intern - Small Molecule Pharmaceutics

Start Date: May/June 2022
Length of Assignment: 12 weeks
Location: Virtual
Preferred Majors/Disciplines: Mechanical engineering, Chemical engineering, Physics
Education Level: Undergraduates who have completed at least three years of undergraduate coursework at a university, recent grads within two years, current graduate students (MS or PhD).
We are seeking a virtual summer intern in the Small Molecule Pharmaceutics (SMP) group in the Small Molecule Pharmaceutical Sciences (SMPS) organization in Genentech Research and Early Development (gRED). SMPS is responsible for the pharmaceutical development of gRED small molecule drug candidates.
Responsibilities: The main responsibility of the intern program is to create a graphic user interface (GUI) for pharmaceutical powder flow prediction, particularly upon hopper discharging. Specific activities include:
  • Review and adapt existing powder flow models based on the radial stress field theory.
  • Create codes using a common programming language to calculate pharmaceutical powder flow pattern and flow obstruction risks (arching and ratholing) based on the models.
  • Generate the GUI to allow easy implementation of powder flow prediction.
  • Validate the codes and GUI by comparing the predicted results with the outcomes from real-life drug product manufacturing.
Qualifications: Background in mechanical engineering, chemical engineering or physics. Strong programming/coding skills and experience with numerical techniques are required. Proficient in programming languages such as Python, C++, or MATLAB. Proven track record developing mathematical models to support process simulation or a background in other advanced modeling applications is a plus.