Senior Scientist Molecular Biology & Discovery
About Invenra:
We are a rapidly expanding and well-funded biotechnology company focused on employing cutting edge protein engineering and multi-specific antibodies to discover therapeutic solutions to challenging diseases. At Invenra, we start with biology, then employ our extensive technology toolbox and efficient discovery engine to design and create first- and best-in-class drug candidates. Using our proprietary B-BODY®, SNIPER® and CLUSTR® technologies, we have generated a robust pipeline of next-generation multi-specific antibodies to address unmet therapeutic needs in immuno-oncology and autoimmunity. Invenra’s employee-focused management and flexible work environment creates a culture of energy and innovation where everyone makes a difference, and everyone benefits from success. For more information, please visit www.invenra.com.
Position Summary:
Invenra is seeking an enthusiastic Senior Scientist with a strong background in cutting-edge Molecular Biology and antibody library building. As part of the Discovery group, the successful applicant will work cross-functionally with Discovery and Protein Engineering to improve our process and throughput, develop next generation libraries, and continually improve our bispecific platform.
Key Responsibilities:
- Design and perform molecular biology experiments, oversee their execution, and interpret/communicate results effectively to the team in meetings.
- Actively involved in optimizing nucleic acid manipulation from single cells in collaboration with our innovation team.
- Perform laboratory procedures following SOPs that includes DNA extraction, cloning, mRNA isolation, cDNA synthesis, PCR and Next Generation Sequencing.
- Coordinate molecular biology research activities with scientists specializing in other fields (Cell Biology and Protein Engineering).
- Support the development, application, and optimization of DNA constructs for genetic modification of cell lines.
- Evaluates new molecular biology technologies to enhance or complement our current research.
- Maintain laboratory notebooks and assist in drafting SOPs and preparing workplans, reports, manuscripts, and presentations.
Required Education, Experience, and Competencies:
- M.S., or Ph.D. in biochemistry, molecular and cellular biology, immunology, or related area AND 3+ year experience (M.S.) or 10+ years’ experience (B.S.) in relevant industrial or academic laboratory.
- Experience developing/optimizing protocols for nucleic acid cloning, amplification, modification, and expression analysis.
- Working knowledge of vector design for gene expression, genetic reporter systems and genome engineering applications – background in phage/yeast display biology will be considered as a plus.
- Experience optimizing/developing protocols for DNA assembly and library constructions for applications such as protein engineering, mRNA and/or phage display is a plus.
- Basic knowledge of the DNA analysis software such as SnapGene is a plus.
- Some Familiarity with stem cell tissue culture and phage and yeast display platforms is a plus.
- Experience in ddPCR or other emulsion-based strategies is a plus
- Experience building and running selections on biomolecular libraries.
- Proven ability to design well-controlled experiments.
- Strong team player with good communication skills.
Preferred but not required:
- General knowledge of immunology and antibody structure-function relationship is a plus.
Note: All job candidates must be authorized to work in the United States.
Benefits:
Include a competitive compensation and benefits package composed of health and dental benefits, 401k match, stock option grants, PTO, tuition reimbursement, a generous bonus plan and relocation assistance. At Invenra, we believe in maintaining the highest ethical standards and ensuring that all employees have a good work-life balance.
Invenra is an Equal Opportunity Employer. Invenra is committed to a diverse workforce. We believe every individual brings their own unique experience, and these experiences foster innovation and success. We are enthusiastically inclusive of age, race, creed, color, disability, marital status, sex, national origin, ancestry, sexual orientation, and military service.