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Scientist, In Process Testing

Job duties include for the Scientist in the In-Process Testing (IPT) Group, include, but are not limited to in-process testing for Process Development runs, testing of upstream and downstream samples, evaluating novel equipment, and performing a range of additional varied work activities including:

  • Tissue culture and maintenance of mammalian cell lines
  • Leading in writing and reviewing R&D and PD protocols, PDPRs, PDTRs, methods, SOPs, analyzing results, and drafting reports in support of R&D and PD processes and analytics.
  • Leading teams tasked with in-process testing
  • Performing in-process testing
  • Training of new employees
  • Communication with clients
  • Serving as the lead for testing for various programs and projects
  • Assist and lead Lab Technicians in organizing daily activities
  • General molecular biology methods associated with cloning, PCR, gel electrophoresis, viral assays, protein analytical assays, and virus/vector propagation
  • Performing and leading analysis of media, culture, and products
  • Hands-on lab work associated with adherent or suspension cell culture, medium/buffer preparation, and cleaning/decontaminating of biosafety cabinets and incubators
  • Play a significant role in research, product, and process development for both current and novel products
  • Perform work in a BSL-1, -2, or -3 environment
  • Organize and manage laboratory inventory including procurement of supplies and materials needed for protocol execution
  • Initiation of investigations and implementation of resulting corrective actions into existing procedures
  • Lead and organize training of Quality Control personnel prior to and during assay transfer
  • Maintain PD inventory supply and ordering
  • Work as a team with assay development, process development, QC, manufacturing, QA, and other departments as needed
  • Contribute to the maintenance of laboratory equipment and laboratory support operations
  • Analyze assay results and monitor trending data to inform PD runs
  • All other tasks as needed or assigned by supervisor

Requirements

  • PhD degree in molecular biology, biochemistry, chemistry, or related field
  • BA or BS degree in molecular biology, biochemistry, chemistry, or related field plus 5 years of experience
  • MS degree in molecular biology, biochemistry, chemistry, or related field plus 3 years of experience
  • 2 years of cell culture experience, using aseptic techniques

Experience performing and developing analytical assays, including

  • ddPCR and/or qPCR
  • ELISA techniques
  • TCID50, IU Titer, Plaque assays
  • Residual host cell DNA and residual host cell protein
  • Western blots, SDS-PAGE, Alkaline gel electrophoresis
  • HPLC
  • Experience with data analysis and data management
  • Strong leadership, technical, communication, and organization skills in a teamwork environment
  • Strong verbal/written and interpersonal communication skills as a team player and willing to work in an environment where individual initiative, collaboration, and accountability are valued
  • Ability to work weekends independently with minimal supervision in an organized manner