You are viewing a preview of this job. Log in or register to view more details about this job.
Email
An outstanding postdoctoral position is available at the UCLA Division of Cardiology and the Broad Stem Cell Research Center. We are a dynamic group interested in cardiovascular development and cardiac fibrosis. We use novel transgenic mouse models and a variety of approaches, including lineage tracing, somatic cell reprogramming, transplantation studies, and parabiosis to understand how cardiac fibrosis is regulated by different sub-population of fibroblasts, pericytes and immune cells. Our lab has identified the developmental origin of cardiac fibroblasts and we continue to explore this field to investigate how they can be manipulated to promote cardiac regeneration with minimal scar formation.
We are also interested in longevity and stem cell functionality with aging, specifically to understand and ameliorate the decline in tissue regenerative capacity with age. The long-term goal is to determine whether young blood may provide beneficial effect in promoting cardiac repair after injury.
Working independently but in close consultation with the Principal Investigator and other Research Scientists, you will perform routine and complex laboratory procedures throughout the training period, and may develop, adapt, and implement new research techniques and protocols while analyzing and interpreting data. You will participate in publications and presentations as author or co-author and may assist in the preparation of grant proposals, but are not responsible for generating grant funds.
The successful applicant will hold a Ph.D. and/or M.D. with less than 2 years of postdoctoral experience with expertise in the following:
  • A solid understanding of cardiovascular development and cardiovascular progenitor fate commitment is required.
  • Skills in isolation and characterization of different cardiac cell types from mouse hearts. Also, skills in culture and maintenance of mammalian cell lines and primary human cells.  
  • Skills in cardiac tissue histology and proficiency in microscopy. 
  • Experience in cell manipulation, flow cytometry and cell sorting, cell tracking, and advanced cell imaging tools.
  • Experience working with CRISPR/Cas9 or other related genome editing modalities preferred.
  • Experience in standard molecular biology techniques (eg. Cloning, qRT-PCR).
  • Computational processing and analysis of genome scale data including bulk and single-cell or single-nucleus ATAC-seq, ChIP-seq, RNA-seq, or proteomics is highly desired.
  • Ability to multitask and complete work on time. Ability to contribute and work in a cross-functional, multi-disciplinary team environment.
  • Excellent verbal and written communication skills in English.
  • Well organized, able to plan work appropriately. Attention to detail. Strong problem-solving skills.